Recent advances in zirconium-catalyzed asymmetric carboalumination (”Zaca” Reaction). Efficient protocols for catalytic asymmetric carbon-carbon bond formation

ORGN 37

Ei ichi Negishi, negishi@purdue.edu1, Ze Tan, tanze@purdue.edu2, Bo Liang, bliang@purdue.edu2, and Tibor Novak, trnovak@purdue.edu2. (1) Department of Chemistry, Purdue University, West Lafayette, IN 47907-1393, (2) Herbert C. Brown Laboratories of Chemistry, Purdue University, West Lafayette, IN 47907-1393
A highly efficient and all-catalytic asymmetric method for carbon–carbon bond formation and its application to the syntheses of reduced polypropionates and other natural products will be discussed with emphasis on recent results. The natural product targets to be discussed include siphonarienes, scyphostatin sidechain, 2,4,6,8-tetramethyldecanoic acid, a preen gland wax component of graylag goose, Anser anser, and reduced polypropionate fragments of ionomycin, borrelidin, and doliculide.
 

Current Aspects of Synthetic Organic Chemistry
1:10 PM-5:00 PM, Sunday, 13 March 2005 Convention Center -- Ballroom 20A-B, Oral

Division of Organic Chemistry

The 229th ACS National Meeting, in San Diego, CA, March 13-17, 2005