ORGN 121 |
| The readily available enantiomerically pure tetrahydropiperidine scaffold 1 is a versatile building block for the synthesis of libraries of various types of substituted piperidines. Iodination, followed by Pd-catalyzed Suzuki and Sonogashira coupling reactions leads to the corresponding alkyl- and aryl-substituted pipecolic acid derivatives. Introduction of vinyl substituents provides 1,3-dienes that are well-suited for Diels-Alder reactions. Furthermore, oxidation of the enamide eventually gives rise to series of hydroxylated pipecolic acid derivatives.
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Heterocycles, Aromatics, Materials, Devices, Switches, Combinatorial Chemistry, Metal-Mediated Reactions
8:00 PM-10:00 PM, Sunday, 13 March 2005 Convention Center -- Hall D, Poster
Division of Organic Chemistry |
