Binding properties of cavitand-based water soluble receptors

ORGN 741

Clemens H. Haas, chaas@scripps.edu, Shannon M. Biros, and Julius Rebek Jr., jrebek@scripps.edu. The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd, MB-26, La Jolla, CA 92037
One aspect of biological chemistry is the development of simple and artificial models of biological functions. Artificial models developed in molecular recognition chemistry have demonstrated the importance of complementarily in size, shape, and functional groups at the molecular level for selective host-guest binding. We have previously described a cavitand-based receptor bearing four carboxylate groups on the upper rim which forms kinetically stable complexes in water. We now introduce a complementary cavitand presenting four cationic functionalities. The influence of the charged groups in binding will be discussed in detail.
 

Asymmetric Reactions, Molecular Recognition, Self Assembly, Bioorganic Chemistry, Process R&D
8:00 PM-10:00 PM, Wednesday, 16 March 2005 Convention Center -- Hall D, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, 14 March 2005 Convention Center -- Sails Pavilion, Sci-Mix

Division of Organic Chemistry

The 229th ACS National Meeting, in San Diego, CA, March 13-17, 2005