ORGN 167 |
| We seek to develop catalytic metalloantibody mimics of the lipoxygenase enzymes, which catalyze the selective hydroperoxidation of lipid 1,4-dienes, via C-H activation. The design of the ligands is based by the known geometry of the lipoxygenase enzymes' active site, which includes a tris-imidazole unit with a tethered carboxylic function (R2); a dienyl substrate recognition element is also included (R3). A short and high yielding synthesis of the biologically relevant 4(5)-tris-imidazole ligands has been devised. These ligands possess at the C-2 position of the imidazole ring an open site for further functionalization. Progress of the ongoing effort to functionalize these tripods in order to obtain appropriate tetradentate ligands will be reported.
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Heterocycles, Aromatics, Materials, Devices, Switches, Combinatorial Chemistry, Metal-Mediated Reactions
8:00 PM-10:00 PM, Sunday, 13 March 2005 Convention Center -- Hall D, Poster
Division of Organic Chemistry |
