ORGN 763 |
| The last few years have witnessed a spectacular advancement in new catalytic methods based on metal-free organic molecules. In many cases, these small compounds give rise to extremely high enantioselectivitys. Chiral amines play a main role in this expanding area. Recent studies have shown that organic catalysts bearing chiral cyclic amines such as proline-derived compounds and modified chinchona alkaloids are promising catalysts. We describe the synthesis of new pseudo-peptidic chiral platforms as organocatalysts which are derived from natural amino acids. The presence of three five-membered heteroaromatic rings leads to a rigid scaffold. Different functional groups (R1-4) are introduced to tune the catalytic activity of the platform. We expect to catalyze enantioselectively reactions using these platforms as chiral Lewis-base/nucleophilic catalysts. In studies, we carried out on the 1,4-addition of thiols to cyclic enones, organic asymmetric catalysis by our compounds was observed. Recently we have been working on the development of new pseudo-peptidic platform-catalyzed enantioselective reactions.
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Asymmetric Reactions, Molecular Recognition, Self Assembly, Bioorganic Chemistry, Process R&D
8:00 PM-10:00 PM, Wednesday, 16 March 2005 Convention Center -- Hall D, Poster
Sci-Mix
Division of Organic Chemistry |
