ORGN 56 |
| The development and utilization of a continuous-flow hydrogenation device for the rapid optimization of the reduction of novel compounds is discussed. The device allows the operator to monitor the progress of the reaction and to change the pressure and temperature freely, between 1-100 bar and 25-100˘ŞC. As a result of the optimization process selective or targeted reduction of several novel heterocyclic systems can be achieved, including a zwitter ionic system (1) as well as products of various multicomponent reactions prepared by parallel synthesis. The application of the device towards automative high-throughput hydrogenation as part of a final combinatorial library step will also be demonstrated. The use of the device for the deuteration of compounds through the addition of deuterium gas across a double bond is also discussed.
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Combinatorial, Parallel, and Solid-Phase Chemistry
1:00 PM-4:20 PM, Sunday, 13 March 2005 Convention Center -- Room 10, Oral
Division of Organic Chemistry |
