Peptide synthesis by using cycloalkane-based thermomorphic system and application to flow system

ORGN 526

Ai Tsuruyama1, Akihiro Ohmori, ao0487@moritex.co.jp1, Shokaku Kim, shokaku8@cc.tuat.ac.jp2, and Kazuhiro Chiba, chiba@cc.tuat.ac.jp2. (1) Bioscience research institute, Moritex Corporation, 1-3-3, Azamino-minami , Aoba-ku, Yokohama, Japan, (2) Laboratoy of Bio-organic Chemistry, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo, Japan
We found that combination of typical organic solvents composed of cycloalkane and quantified aprotic polar organic solvents realized an effective, biphasic thermomorphic system that enable a practical application of a solution-phase peptide synthesis. This reaction and separation media composed of non-polar cyclohexane and polar, aprotic solvents allow for extremely efficient reactions by the association of apolar products and polar substrates or catalysts in a one-phase solution, which could be spetially separated cycloalkane-based liquid phase method was compatible with a sequential flow synthesis of peptide and its derivatives.
 

New Reactions, Methodology, Total Synthesis, Physical Organic Chemistry
8:00 PM-10:00 PM, Tuesday, 15 March 2005 Convention Center -- Sails Pavilion, Poster

Division of Organic Chemistry

The 229th ACS National Meeting, in San Diego, CA, March 13-17, 2005