Liquid-phase oligosaccharide and its derivatives synthesis using a cycloalkanes soluble platform

ORGN 505

Akihiro Ohmori, ao0487@moritex.co.jp1, Ai Tsuruyama1, Shokaku Kim, shokaku8@cc.tuat.ac.jp2, and Kazuhiro Chiba, chiba@cc.tuat.ac.jp2. (1) Bioscience research institute, Moritex Corporation, 1-3-3, Azamino-minami , Aoba-ku, Yokohama, Japan, (2) Laboratoy of Bio-organic Chemistry, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo, Japan
Introduction of long-alkyl chain group as protecting group of glycosyl acceptor made it possible to dissolve selectively in the cycloalkanes solvents of the biphasic solution composed of cycloalkanes and polar solvents. Excess polar reagent or catalysts were removed easily by biphasic liquid-liquid extraction. Cycloalkanes soluble platforms enabled the efficient oligosaccharide synthesis high purity. This synthetic method improved some of disadvantage of solid-phase oligosaccharide synthesis.
 

New Reactions, Methodology, Total Synthesis, Physical Organic Chemistry
8:00 PM-10:00 PM, Tuesday, 15 March 2005 Convention Center -- Sails Pavilion, Poster

Division of Organic Chemistry

The 229th ACS National Meeting, in San Diego, CA, March 13-17, 2005