ORGN 281 |
| Koumine, isolated from the Chinese medicinal plant Kou-wen, is a member of the tetrahydro-β-carboline sub-group of the indole alkaloids and possesses a complex three-dimensional cage structure. Our efforts toward the total synthesis of koumine utilize a tandem [2+2] cycloaddition/retro-Mannich reaction to provide spiro-fused 6,5-bicyclic imine 2. The construction of tricycle 3 and studies toward the completion of koumine will be presented.
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Total Synthesis of Complex Molecules
8:00 AM-12:00 PM, Monday, 14 March 2005 Convention Center -- Room 10, Oral
Division of Organic Chemistry |
