Virus based scaffolds for nanoscale organic/inorganic hybrid materials

ORGN 66

Amish A. Patel, patela@berkeley.edu, Tara L. Schlick, schlick@berkeley.edu, and Matthew B. Francis, francis@cchem.berkeley.edu. Department of Chemistry, University of California, Berkeley, 733 Latimer Hall, Berkeley, CA 94720-1460
Viral capsids are composed of multiple copies of identical proteins that can assemble in vitro into monodisperse structures possessing nanoscale features. The goal of this research is to utilize virus-based scaffolds for the construction of nanoscale organic/inorganic hybrid materials. To do this, a modular synthetic approach to append new functional groups to the exterior and interior surfaces of the tobacco mosaic virus (TMV) has been developed. The exterior surface of TMV is modified with various ketone-bearing diazonium reagents to allow the attachment of gold nanoparticles through a covalent oxime linkage. Water-soluble gold nanoparticles bearing complementary functional groups for attachment to TMV were synthesized to investigate plasmon resonance effects of the resulting arrays. The development, scope and applications of this technology will be presented.
 

Materials, Devices, and Switches
1:00 PM-5:00 PM, Sunday, 13 March 2005 Convention Center -- Room 9, Oral

Division of Organic Chemistry

The 229th ACS National Meeting, in San Diego, CA, March 13-17, 2005