Developing functional assays for detecting chemical agents using synthetic ion channels

ORGN 234

Jerry Yang, jerryyang@ucsd.edu1, Steven Blake, stevenb@ucsd.edu1, Jason Rose, jjoerose@umich.edu2, and Michael Mayer, mimayer@umich.edu2. (1) Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Dr, MC 0358, La Jolla, CA 92093-0358, (2) Department of Biomedical Engineering and Chemical Engineering, University of Michigan, 2200 Bonisteel Blvd, Ann Arbor, MI 48109-2099
Ion channels are pores in cellular membranes that allow the transport of ions across a lipid bilayer. These pores permit the amplification of a cellular signal and can be gated by an external biological, chemical, or physical stimulus. This research describes methods to synthesize derivatives of natural ion channel-forming peptides that modulate ion channel conductance, gated by tailored chemical or biological stimuli. The goal of this research is to develop an ultra-sensitive functional assay for the detection of reactive chemical agents in solution for diverse applications ranging from the screening of molecules that have specific catalytic function to the detection of chemically active environmental and biological compounds.
 

Heterocycles, Aromatics, Materials, Devices, Switches, Combinatorial Chemistry, Metal-Mediated Reactions
8:00 PM-10:00 PM, Sunday, 13 March 2005 Convention Center -- Hall D, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, 14 March 2005 Convention Center -- Sails Pavilion, Sci-Mix

Division of Organic Chemistry

The 229th ACS National Meeting, in San Diego, CA, March 13-17, 2005