ORGN 27 |
| Along with scientists at CombiMatrix, we are working to develop the synthetic chemistry that can be accomplished at pre-selected sites on an electrochemically-addressable chip. As part of this effort, we have begun to explore the potential for using Pd(0) catalysts on the chips. The availability of Pd(0) catalyzed reactions would dramatically expand the types of molecules that can be constructed on the chip. Initially, we are using selected electrodes on the chips as cathodes in order to reduce Pd(II) to Pd(0). The Pd(0) is then confined to the desired reaction sites by adding a reagent to the solution above the chip that reconverts the Pd(0) generated back into Pd(II). An example of how this strategy can be employed is illustrated in the following figure. In this experiment, a Heck reaction was utilized to place a pyrene containing molecule at selected electrodes. The chip was then imaged using the pyrene as a fluorescence probe. In the figure, the bright spots indicate selected reaction centers. The details of this experiment plus general strategies for using Pd(0) chemistry on the chips will be discussed.
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Combinatorial, Parallel, and Solid-Phase Chemistry
8:00 AM-11:40 AM, Sunday, 13 March 2005 Convention Center -- Room 10, Oral
Division of Organic Chemistry |
