ORGN 702 |
| We recently described a new approach for the synthesis of artificial alpha-helices that involves replacement of one of the main chain hydrogen bonds with a carbon-carbon bond derived from a ring-closing metathesis reaction. The salient feature of this hydrogen-bond surrogate (HBS) approach is that it affords constrained alpha-helices without restricting access to the molecular recognition surfaces or altering the side chain functionalities. We know show that these HBS alpha-helices can target chosen protein receptors with high affinity. This poster will describe our efforts to target the Bcl-xl protein, which is involved in the regulation of apoptosis.
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Asymmetric Reactions, Molecular Recognition, Self Assembly, Bioorganic Chemistry, Process R&D
8:00 PM-10:00 PM, Wednesday, 16 March 2005 Convention Center -- Hall D, Poster
Division of Organic Chemistry |
