Reverse polarity C-glycosidation and benzannulation of Fischer carbene as key steps for total synthesis of ravidomycin

ORGN 517

Fei You, fy8n@virginia.edu, Department of Chemistry, Brown University, Providence, RI 02912 and Kathlyn A Parker, Department of Chemistry, State University of New York at Stony Brook, Stony Brook, NY 11794.
Ravidomycin is an aryl C-glycoside with a complex structure and reported antitumor activity.  Benzannulation of an appropriately substituted chromium carbene  provides the complete carbon skeleton in an advanced model for the key step of the total synthesis.

 

New Reactions, Methodology, Total Synthesis, Physical Organic Chemistry
8:00 PM-10:00 PM, Tuesday, 15 March 2005 Convention Center -- Sails Pavilion, Poster

Division of Organic Chemistry

The 229th ACS National Meeting, in San Diego, CA, March 13-17, 2005