Award Address (Earle B. Barnes Award for Leadership in Chemical Research Management, sponsored by The Dow Chemical Company). Chemistry and the CYPHER® Sirolimus-eluting coronary stents

ORGN 355

Cynthia A. Maryanoff, Cordis Corporation, a Johnson & Johnson Company, Welsh & McKean Roads, Spring House, PA 19477
A stent is a small expandable metal tube that acts like a structural scaffold holding an artery open and allowing blood to flow to the heart. The CYPHER® Sirolimus-eluting Coronary stent combines a proven metal stent with Sirolimus, an immunosuppressive-type medication. Sirolimus helps to limit normal tissue overgrowth following coronary stent implantation. Chemical aspects of the manufacture of CYPHER® Sirolimus-eluting Coronary stents will be discussed.