ORGN 10 |
| Dendrimers are attractive polymers for a variety of biomedical applications since they are readily manipulated, multivalent and monodisperse macromolecules. In practice, the synthesis of monodisperse (pure) dendrimers is difficult to attain, particularly when a large scale preparation is desired. Dendrimers based on triazines offer distinct advantages including tractable convergent syntheses, significant differences in physical properties of the amino monochlorotriazine intermediates, solubility in a range of solvents that can be modified through the use of appropriate functional groups, and the relative ease in which crystalline intermediates may be isolated. Moreover, chemoselectivity may be exploited at the three reactive positions of the parent compound, cyanuric chloride, enabling routes to compositional complexity. Developments in the synthesis of triazine dendrimers will be detailed, and methodology to eliminate impurities will be discussed. |
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Heterocycles and Aromatics
8:00 AM-12:00 PM, Sunday, 13 March 2005 Convention Center -- Room 11A, Oral
Division of Organic Chemistry |