ORGN 31 |
| Constitutional dynamics in chemical systems represents an emerging method to generate arrays of compounds through reversible reactions or interactions. This process gives access to dynamic libraries encompassing the possible combinations of the available reacting/interacting components, and allows for target-driven generation or amplification of the active constituent(s) of the libraries. The dynamics enables self-screening processes by which the active species become preferentially expressed and can be retrieved from the libraries. In the present study, the implementation of such arrays on biological interactions is illustrated, where dynamic libraries are probed against binding to biological receptors in aqueous media. It is furthermore demonstrated that enzyme catalysts can be used to control the dynamic self-screening process. |
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Combinatorial, Parallel, and Solid-Phase Chemistry
8:00 AM-11:40 AM, Sunday, 13 March 2005 Convention Center -- Room 10, Oral
Division of Organic Chemistry |