ORGN 151 |
| Recently, 6-arylpurine ribonucleosides have been shown to possess cytostatic activity. We now report that 6-(azolyl, alkylthio and fluoro)purine nucleosides undergo Ni/Pd-mediated C-C cross-coupling of these purine derivatives with arylboronic acids to give good yields of 6-arylpurine nucleosides. This procedure works well with both electron-rich and electron-poor arylboronic acids.
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Heterocycles, Aromatics, Materials, Devices, Switches, Combinatorial Chemistry, Metal-Mediated Reactions
8:00 PM-10:00 PM, Sunday, 13 March 2005 Convention Center -- Hall D, Poster
Division of Organic Chemistry |
