A highly efficient enantioselective synthesis of 2-methyl chromans with studies in the Pd-catalyzed aryl ether ring formation

ORGN 159

Michael Palucki, michael_palucki@merck.com and Nobuyoshi Yasuda. Department of Process Research, Merck Research Laboratories, P.O.Box 2000, Rahway, NJ 07065-0900
An enantioselective synthesis of substituted 2-methyl chromans was accomplished in 4 steps using four sequential Pd-catalyzed reactions. A study in the key palladium-catalyzed regioselective aryl ether ring formation of two different substrates was also carried out.

 

Heterocycles, Aromatics, Materials, Devices, Switches, Combinatorial Chemistry, Metal-Mediated Reactions
8:00 PM-10:00 PM, Sunday, 13 March 2005 Convention Center -- Hall D, Poster

Division of Organic Chemistry

The 229th ACS National Meeting, in San Diego, CA, March 13-17, 2005