Asymmetric dihydroxylation of allenes

ORGN 787

Steven A. Fleming, steve_fleming@byu.edu1, Renmao Liu, rliu@chem.byu.edu1, J. Ty Redd, Redd@suu.edu2, and Sean M. Carroll, Carr6614@Student.Suu.Edu2. (1) Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, (2) Chemistry, Southern Utah University, 351 West Center, Cedar City, UT 84720
We have investigated the performance of allenes in asymmetric dihydroxylation. A novel approach for synthesis of ¦Á-hydroxy ketones with excellent regio- and enantioselectivity has been established by asymmetric dihydroxylation of terminal allenes. Currently we are extending this methodology to 1,3-disubstituted chiral allenes and have obtained promising results for both kinetic resolution and asymmetric dihydroxylation.
 

Asymmetric Reactions, Molecular Recognition, Self Assembly, Bioorganic Chemistry, Process R&D
8:00 PM-10:00 PM, Wednesday, 16 March 2005 Convention Center -- Hall D, Poster

Division of Organic Chemistry

The 229th ACS National Meeting, in San Diego, CA, March 13-17, 2005