ORGN 782 |
| Non-racemic allylic hydroxy phosphonates are formed by asymmetric phosphonylation of aldehydes or cross-metathesis of an alkene and the acrolein-derived phosphonate. These hydroxy phosphonates display some of the rich chemistry associated with allylic alcohols. However, the steric and electronic influence of the phosphorus moiety can enhance the regio-and stereochemical outcome of the reaction. Recent results in the inter- and intra-molecular addition of nitrogen and oxygen nucleophiles and application in the synthesis of heterocycles will be described.
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Asymmetric Reactions, Molecular Recognition, Self Assembly, Bioorganic Chemistry, Process R&D
8:00 PM-10:00 PM, Wednesday, 16 March 2005 Convention Center -- Hall D, Poster
Division of Organic Chemistry |
