ORGN 26 |
| The solid-phase organic chemistry offers an efficient route to construct large libraries of small organic molecules for drug discovery. 1,4-Naphthoquinone derivatives display a wide spectrum of biological activities. This presentation involves microwave-assisted solid-phase Dotz benzannulation of 1 with various alkynes, followed by the oxidation of the resulting resin-bound 1,4-naphthols 3. This pathway leads to the biologically important 2,3-disubstiuted-1,4-naphthoquinone derivatives in good to moderate yields. In addition to alkynes, the reaction has been extended to 1,3-diynes.
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Combinatorial, Parallel, and Solid-Phase Chemistry
8:00 AM-11:40 AM, Sunday, 13 March 2005 Convention Center -- Room 10, Oral
Division of Organic Chemistry |
