ORGN 613

A facile 2-amino-trifluoroacetophenones are readily synthesized by the reaction of o-trimethylsilylaryl triflates and CsF with trifluoroacetanilides. This reaction affords good to excellent yields of the desired products under very mild reaction conditions. This chemistry tolerates a variety of functional groups, including ester, amide and halide groups and can be extended to the synthesis of a variety of potentially biologically active products.