Synthesis of anti-prion active acridine derived compounds

ORGN 150

Rene Csuk, rene.csuk@chemie.uni-halle.de and Alexander Barthel. Institute of Organic Chemistry, Martin-Luther-University Halle-Wittenberg, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany
Substituted acridines have been in use as anti-malarials for many years quite successfully. Quite recently, the scope of potential applications was dramatically enlarged due to the finding, that several of them show quite promising activity in vitro against prion based diseases. A convenient route to these compounds was established by using a modified Buchwald-Hartwig amination sequence. The compounds were shown to possess anti-prion as well as anti-amyloidogenic activity.

 

Heterocycles, Aromatics, Materials, Devices, Switches, Combinatorial Chemistry, Metal-Mediated Reactions
8:00 PM-10:00 PM, Sunday, 13 March 2005 Convention Center -- Hall D, Poster

Division of Organic Chemistry

The 229th ACS National Meeting, in San Diego, CA, March 13-17, 2005