ORGN 351 |
Our group has conducted research on numerous microbial products. We have established novel, customised and specific methods for screening. We have discovered more than 330 new microbial products over the past 30 years. Of these, about 15 have contributed significantly to improvements in human welfare and the advancement of scientific knowledge through their use as medicines, animal health agents, agrochemical agents or as reagents for biochemical research. In addition, more than 50 of the compounds we discovered have been targeted by synthetic organic chemists and have subsequently been instrumental in expediting progress in organic chemistry. After a brief review of the highlights of our past research, I shall talk about four interesting, recently-discovered compounds. These are nafuredin (an inhibitor of helminth NADH-furmarate reductase); atpenin (an inhibitor of succinate-ubiquinone oxidoreductase); lariatin (an antibiotic which specifically inhibits the growth of Mycobacterium spp.); and KOI-0509 (an inhibitor of EPEC type-III secretion).
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Ernest Guenther Award in the Chemistry of Natural Products
8:55 AM-12:00 PM, Tuesday, 15 March 2005 Convention Center -- Ballroom 20A-B, Oral
Division of Organic Chemistry |