ORGN 349 |
| Useful antiparasitic natural products produced by microorganisms, as typified by the avermectins, have been discovered by Prof. Satoshi Omura and co-workers at the Kitasato Institute. In addition, two antiparasitic natural products, nafuredin and borrelidin, have recently been isolated. Nafuredin selectively inhibits NADH-fumarate reductase, which plays a role in a part of the electron transport system involved in energy metabolism found in many anaerobic organisms such as helminths. Borrelidin shows potent antimalarial activity against chloroquine-resistant parasite strains. To facilitate easy access to simplified analogues for structure-activity relationship studies, we have developed methods for the total synthesis of both nafuredin and borrelidin. In this presentation, we detail the results of this total synthesis.
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Ernest Guenther Award in the Chemistry of Natural Products
8:55 AM-12:00 PM, Tuesday, 15 March 2005 Convention Center -- Ballroom 20A-B, Oral
Division of Organic Chemistry |
