ORGN 1 |
| The human genome contains 30,000 or so genes. Scientists from a broad range of disciplines are now working to reveal the structure and function of the proteins encoded by these genes. Their findings could lead to the solution of a multitude of problems in biology and medicine. In addition to analyzing the structure and function of extant proteins, modern protein chemists are working to create new proteins with desirable properties. One approach to enhancing the performance of proteins is to leave essential residues intact, but replace nonessential residues with modules that confer extra conformational stability or resistance to proteolysis without compromising function. The practical benefits of such protein “prosthesis” include endowing chemotherapeutic proteins with the ability to survive longer in vivo or retain activity after oral administration. New methods for the chemical synthesis and semisynthesis of proteins are facilitating this approach. This talk will describe recent advances in protein prosthesis as well as in the synthesis and semisynthesis of proteins. |
|
Ralph F. Hirschmann Award in Peptide Chemistry
8:00 AM-12:00 PM, Sunday, 13 March 2005 Convention Center -- Ballroom 20A-B, Oral
Division of Organic Chemistry |