ORGN 260 |
| DNA serves several functions in a cell, ranging from acting as a molecular scaffold for arrangement of proteins, to encoding of genetic information, transferring biological information, and acting as a catalyst for replication. The development of new molecules that reproduce some of DNA's functions in synthetic systems can lead to new biotechnological tools and to biomedically useful compounds. Three approaches to functional mimicry of DNA will be described: first, a new series of DNA base shape mimics will be introduced as probes of active site tightness in DNA polymerase enzymes. The compounds retain similar shapes but have gradually increasing size, and some are found to have surprising biological activities. The second approach involves the discovery of new composite fluorescent labels and sensors by assembly of oligomeric fluorophores on a DNA backbone. Finally, a molecular strategy for engineering an entire DNA replication pathway in vitro and in cells will be described. |
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Frontiers in Bio-organic Chemistry and Chemical Biology
8:00 AM-11:55 AM, Monday, 14 March 2005 Convention Center -- Ballroom 20 C-D, Oral
Division of Organic Chemistry |