Design and synthesis of labeled Δ9-THC analogs

ORGN 162

Longwu Qi, longwu@scripps.edu, Michael M. Meijler, meijler@scripps.edu, and Kim D. Janda, kdjanda@scripps.edu. Department of Chemistry, The Scripps Research Institute and The Skaggs Institute for Chemical Biology, 10550 N. Torrey Pines Road, La Jolla, CA 92037
D9-THC (tetrahydrocannabinol, 1) is the major psychoactive constituent of marijuana. Radiolabeled and fluorescent THC analogs were synthesized stereoselectively. The labeled analogs will provide a powerful tool for the study of the affinity between THC and anti-THC antibodies, and for high-throughput selection of antibodies against THC as well.

 

Heterocycles, Aromatics, Materials, Devices, Switches, Combinatorial Chemistry, Metal-Mediated Reactions
8:00 PM-10:00 PM, Sunday, 13 March 2005 Convention Center -- Hall D, Poster

Division of Organic Chemistry

The 229th ACS National Meeting, in San Diego, CA, March 13-17, 2005