Lipid nanotubes with cationic inner surfaces self-assembled by unsymmetrical bolaamphiphiles

ORGN 735

Naohiro Kameta, n-kameta@aist.go.jp1, Mitsutoshi Masuda, m-masuda@aist.go.jp2, and Toshimi Shimizu, tshmz-shimizu@aist.go.jp2. (1) Nanoarchitectonics Reserch Center (NARC), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 4, 1-1-1 Higashi, Tsukuba, 305-8562, Japan, (2) Nanoarchitectonics Reserch Center (NARC), National Institute of Advanced Industrial Science and Technology (AIST), and CREST, Japan Science and Technology Agency (JST), Tsukuba Central 4, 1-1-1 Higashi, Tsukuba, 305-8562, Japan
Unsymmetrical bolaamphiphiles, having a 1-glucosamide group at one end of oligomethylene chain and an aminoethylamide group at the other end, self-assembled in water to give lipid nanotubes. Scanning transmission electron microscopy (STEM) showed that the nanotubes have a hollow cylinder structure with 100-110 nm in outer diameters and 70-80 nm in inner diameters. X-ray diffraction (XRD) analysis of the freeze-dried nanotubes was also carried out to elucidate the molecular packing of the nanotubes. The nanotubes consisted of monolayer lipid membranes, in which the molecules are packed in a parallel fashion with an amine-glucose interface. This suggests that the inner surface of the nanotubes is covered with the amino headgroups and the outer surface with the 1-glucosamide headgroups.
 

Asymmetric Reactions, Molecular Recognition, Self Assembly, Bioorganic Chemistry, Process R&D
8:00 PM-10:00 PM, Wednesday, 16 March 2005 Convention Center -- Hall D, Poster

Division of Organic Chemistry

The 229th ACS National Meeting, in San Diego, CA, March 13-17, 2005