Enantioselective desymmetrisations: The first intermolecular Suzuki couplings producing stereodefined sp3 carbon centres

ORGN 107

Luke H. W. Powell and Michael C. Willis. Department of Chemistry, University of Bath, Bath, BA2 7AY, United Kingdom
Prochiral ditriflates can act as substrates in asymmetric Suzuki couplings by using an enantioselctive desymmetrisation strategy. The products are obtained with selectivities up to 86% ee and contain a quaternary carbon centre and a synthetically useful vinyl triflate functionality.

 

Asymmetric Reactions and Syntheses, Metal-Mediated Reactions, Materials, Molecular Recognition
8:00 PM-10:00 PM, Sunday, August 22, 2004 Pennsylvania Convention Center -- Hall D, Poster

Division of Organic Chemistry

The 228th ACS National Meeting, in Philadelphia, PA, August 22-26, 2004