ORGN 214 |
Allenes and transition metal catalysis: A diverging strategy
| Kay M. Brummond, Department of Chemistry, Department of Chemistry, University of Pittsburgh, 234 Chevron Science Center, Pittsburgh, PA 15260 |
| Elegant and rapid assembly of complex organic substructures is a shared goal among synthetic chemists, and successful synthetic strategies can have far-reaching impact in a range of areas. In this presentation transition metals are used to catalyze new carbon-carbon bond forming processes with particular emphasis on highly unsaturated compounds. Application of these new methods to the synthesis of the natural products, suberosenone , 15-deoxy-D12,14 prostaglandin J2 and guanacastepene will be discussed. Moreover, inspired by Nature’s structural diversity in secondary metabolite synthesis, a diverging strategy for assembling multiple architecturally unique compounds from a single pivotal substrate is being applied to diversity-oriented synthesis for the preparation of natural product-like libraries. 
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