Chemoenzymatic asymmetric synthesis of potential phosphodiesterase inhibitors from a nitroso-diels-alder-derived amino cyclopentenol

ORGN 528

May Xiao Wu Jiang, Namal C. Warshakoon, and Marvin M. Miller. Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556
An efficient chemoenzymatic resolution of nitroso-Diels-Alder-derived amino cyclopentenol will be discussed. Further application of enantiopure amino cyclopentenol in the synthesis of phosphodiesterase inhibitors via Pd(0)-catalyzed intramolecular cyclization under basic conditions will be explored. The biological test results of the products will also be reported.

 

Practical Synthesis and Total Synthesis of Complex Molecules
8:00 AM-12:00 PM, Wednesday, August 25, 2004 Pennsylvania Convention Center -- 201B, Oral

Division of Organic Chemistry

The 228th ACS National Meeting, in Philadelphia, PA, August 22-26, 2004