ORGN 211 |
| Mary K. Boyd, Department of Chemistry, Department of Chemistry, Loyola University Chicago, 6525 N. Sheridan Rd., Chicago, IL 60626 |
| The 9-phenylxanthyl (pixyl) and 9-phenylthioxanthyl (S-pixyl) moieties are effective photocleavable protecting groups for primary alcohols, including the 5'-hydroxyl functionality of nucleosides. We have investigated several analogues of the pixyl and S-pixyl protecting groups, with substitution on the xanthyl backbone and on the 9-aryl functionality. Appropriate substitution increases the long wavelength absorption of the protecting group, improving its utility with nucleosides, and decreases the time for photodeprotection. The S-pixyl moiety was used to synthesize short oligonucleotides, demonstrating its potential application in DNA chip synthesis. |
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Women in Organic Synthesis
8:45 AM-12:00 PM, Monday, August 23, 2004 Pennsylvania Convention Center -- Ballroom A, Oral
Division of Organic Chemistry |