INOR 301 |
| Wen hong Li1, Henry Dai1, Quan Zheng1, Matthew Merritt2, and Craig Malloy2. (1) Departments of Cell Biology and Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Bl, Dallas, TX 75390-9039, (2) Department of Radiology, University of Texas Southwestern Medical Center at Dallas |
| Magnetic resonance imaging (MRI) is a truly non-invasive imaging technique that provides 3-D images of internal structures of living organisms. The capability of being able to probe opaque specimen at high spatial resolutions makes MRI an attractive choice for the in vivo cellular and molecular imaging. We are developing MRI contrast agents for imaging mammalian cells. We have designed and synthesized a novel class of lanthanide complexes for cell labeling and imaging applications. These lipophilic T1-agents can be taken up by intact cell populations in a manner similar to fluorescent labels such as DiI or DiO. Cells labeled with these agents showed dramatic enhancement in image intensity. After implanting labeled beta-cells into nude mice, we could image these cells in encapsulated devices for over two weeks. This part of work may provide us a non-invasive imaging method for the fate mapping of implanted cells continuously over a period of time. |
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The Chemistry of Biological Molecular Imaging
8:30 AM-12:00 PM, Monday, August 23, 2004 Pennsylvania Convention Center -- 108B, Oral
Division of Inorganic Chemistry |