ORGN 610 |
The mechanism of thio acid/azide amidation and application to thioamide synthesis
| Robert V. Kolakowski, Ning Shangguan, Kristin Barlett, and Lawrence J. Williams. Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Rd, Piscataway, NJ 08854 |
| Thio acid/azide coupling reaction that can result in the formation of amide bonds in high yields. The mechanism of amidation reported herein was experimentally determined to proceed via a thiatriazoline intermediate. This reaction and mechanistic framework was extended to dithio acids and azides yielding the corresponding thioamides under mild condition and was shown to be effective in water. 
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New Reactions, Methodology, Heterocycles, Aromatics
8:00 PM-10:00 PM, Wednesday, August 25, 2004 Pennsylvania Convention Center -- Hall D, Poster
Division of Organic Chemistry
The 228th ACS National Meeting, in Philadelphia, PA, August 22-26, 2004
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