ORGN 18 |
Synthesis of both enantiomers of a P-chiral bisphosphine ligand for Rh-catalyzed asymmetric hydrogenation of olefins
| Duan Liu and Xumu Zhang. Department of Chemistry, The Pennsylvania State University, 102 Chemistry Building, University Park, PA 16802 |
| Although a great deal of success has been achieved in asymmetric hydrogenation during the last few decades, with the introduction of hundreds of chiral ligands, the substrate scope for a particular ligand or ligand family is generally very limited with few exceptions. The search for more practical ligands with ready availability, catalytic efficiency, and broad substrate scope remains attractive and important in asymmetric hydrogenation. In this contribution, we wish to report a concise synthesis of a new electron-donating P-chiral bisphosphine ligand in both enantiomeric forms. Highly enantioselective hydrogenation of various functionalized olefins under mild conditions using its Rh complex as a catalyst will be discussed. 
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