Facile quantification of enantiomeric excess and concentration with indicator-displacement assays

ORGN 238

Lei Zhu and Eric V. Anslyn. Department of Chemistry and Biochemistry, The University of Texas at Austin, 1 University Station, A5300, 24th Street and Speedway, Austin, TX 78712
An enantioselective indicator-displacement assay was developed to determine enantiomeric excess (ee) and concentration of alpha-hydroxyacid samples with two independent absorption measurements. The inherent relationship between the absorbance of the indicator-displacement ensemble and the overall concentration and ee of the analyte was established through solution equilibria.

 

Molecular Recognition and Self-Assembly
8:00 AM-12:00 PM, Monday, August 23, 2004 Pennsylvania Convention Center -- 201B, Oral

Division of Organic Chemistry

The 228th ACS National Meeting, in Philadelphia, PA, August 22-26, 2004