ORGN 615 |
Preparation of ketones from nitriles and phosphoranes
| D. F. Taber and Lisi Cai. Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716 |
| The ketone is the central functional group in organic synthesis. One route to a ketone is the addition of an organometallic reagent to the nitrile. The disadvantage of this approach is that any unreacted organometallic reagent is protonated on work-up and so lost. We report an improvement of the McEwen procedure, addition of a phosphorane to the nitrile. The advantage of this approach is that any unreacted phosphonium salt can easily be recovered and reused. 
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New Reactions, Methodology, Heterocycles, Aromatics
8:00 PM-10:00 PM, Wednesday, August 25, 2004 Pennsylvania Convention Center -- Hall D, Poster
Division of Organic Chemistry
The 228th ACS National Meeting, in Philadelphia, PA, August 22-26, 2004
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