Stereoselective preparation of highly substituted olefins

ORGN 582

Christopher T. Meta and Kazunori Koide. Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, PA 15260
We have a developed a method to stereoselectively prepare di-, tri-, and tetra-substituted olefins through trans-addition of a nucleophile and an electrophile across the triple bond of γ-hydroxy-α,β-acetylenic esters. Compounds of this type are versatile synthetic intermediates and are contained in many natural products. The development and scope of the reaction will be discussed.

 

New Reactions, Methodology, Heterocycles, Aromatics
8:00 PM-10:00 PM, Wednesday, August 25, 2004 Pennsylvania Convention Center -- Hall D, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, August 23, 2004 Pennsylvania Convention Center -- Hall D, Sci-Mix

Division of Organic Chemistry

The 228th ACS National Meeting, in Philadelphia, PA, August 22-26, 2004