ORGN 607 |
Concise stereocontrolled synthesis of keto-alcohols
| Partha Ghosh and Lawrence J. Williams. Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor road, Piscataway, NJ 08854 |
| The highly functionalized structural motifs common to complex natural products continue to inspire the development of new reactions and methodologies. Substituted alpha-hydroxy ketones represent a prevalent motif among natural products. For example the epoxymicins and amphidinolides contain alpha-hydroxy ketones or there derivatives. In the course of our studies in natural product total synthesis, we demonstrated that this structural array can be accessed in a concise, stereocontroled manner. Herein we report these findings exemplified by the three step transformation shown below. 
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New Reactions, Methodology, Heterocycles, Aromatics
8:00 PM-10:00 PM, Wednesday, August 25, 2004 Pennsylvania Convention Center -- Hall D, Poster
Division of Organic Chemistry
The 228th ACS National Meeting, in Philadelphia, PA, August 22-26, 2004
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