Ligand, copper, and amine-free Sonogashira reactions of aryl iodides with terminal alkynes

ORGN 153

Sameer Urgaonkar and John G. Verkade. Department of Chemistry, Iowa State University, Gilman Hall, Ames, IA 50011
Conditions for an efficient ligand, copper, and amine-free palladium-catalyzed Sonogashira reaction of aryl iodides with terminal alkynes have been developed. Critical to the success of this new protocol is the use of tetrabutylammonium acetate as the base. Noteworthy features of this method are room temperature conditions and the tolerance of a broad range of functional groups in both reaction partners.

 

Asymmetric Reactions and Syntheses, Metal-Mediated Reactions, Materials, Molecular Recognition
8:00 PM-10:00 PM, Sunday, August 22, 2004 Pennsylvania Convention Center -- Hall D, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, August 23, 2004 Pennsylvania Convention Center -- Hall D, Sci-Mix

Division of Organic Chemistry

The 228th ACS National Meeting, in Philadelphia, PA, August 22-26, 2004