ORGN 341 |
| Neal J. Zondlo, Shalini Balakrishnan, and Devan Naduthambi. Department of Chemistry and Biochemistry, University of Delaware, 206 Lammot DuPont Laboratories, Newark, DE 19716 |
| Organophosphates are a potent class of nerve agents which function via specific inhibition of acetylcholinesterase. These agents have been developed as chemical warfare agents and, due to their ready preparation and acute toxicity, have been and are expected to be used as agents of terrorism. In addition, organophosphates are widely used as pesticides. We have developed a novel, highly sensitive (as sensitive as femtomoles) fluorescent detection scheme for organophosphate nerve agents. The detection scheme displays very high specificity for nerve agents and the specificity may be tailored via modification of the enzyme used. The reagents used may be prepared inexpensively and the assay conducted rapidly. A modified version of the scheme may also be used as a novel fluorescent assay for acetylcholinesterase activity. |
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Materials, Devices, and Switches
1:00 PM-5:00 PM, Tuesday, August 24, 2004 Pennsylvania Convention Center -- 201B, Oral
Division of Organic Chemistry |