ORGN 82 |
| Xumu Zhang, Yongjun Yan, and Yongxiang Chi. Department of Chemistry, The Pennsylvania State University, 152 Davey Lab, University Park, PA 16802 |
| Compared with diphosphines and diphospholanes, phosphine-phosphite and phosphine-phosphinite ligands are rarely reported for asymmetric hydrogenation. These under-reported ligands typically suffer from limitations such as low enantioselectivity and narrow substrate scope. Herein, we report the design and synthesis of two new phosphine-phosphite and phosphine-phosphinite ligands prepared from BINOL. Preliminary results showed that these ligands are highly enantioselective in Rh-catalyzed asymmetric hydrogenation of a variety of dehydroaminoacid derivatives. |
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Asymmetric Reactions and Syntheses, Metal-Mediated Reactions, Materials, Molecular Recognition
8:00 PM-10:00 PM, Sunday, August 22, 2004 Pennsylvania Convention Center -- Hall D, Poster
Division of Organic Chemistry |