ORGN 156 |
Selective cross coupling and metalation reactions of pyridazinones
| Thomas M. Stevenson, Brett A. Crouse, Tho V. Thieu, Cristina Gebreysus, and Donna L. Piotrowski. Stine-Haskell Research Center, DuPont Crop Protection, P.O. Box 30, Newark, DE 19714 |
| We have investigated the use of the pyridazinone ring system as a cyclic version of the methoxyacrylate pharmacophore of the fungicidal natural product strobilurin A. Our synthetic approach to these compounds was based on Suzuki and Stille coupling reactions of halopyridazinones. In addition to these coupling reactions we have investigated a number of other cross coupling reactions of these substrates. We also have found a simple way to differentiate the 4 and 5 positions of the pyridazinones to enable selective functionalization. Halogen-metal exchange reactions of the pyridazinones also proved successful. 
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Asymmetric Reactions and Syntheses, Metal-Mediated Reactions, Materials, Molecular Recognition
8:00 PM-10:00 PM, Sunday, August 22, 2004 Pennsylvania Convention Center -- Hall D, Poster
Division of Organic Chemistry
The 228th ACS National Meeting, in Philadelphia, PA, August 22-26, 2004
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