We have developed a new platform for combinatorial synthesis that combines microwave-assisted organic reactions with the SPOT-synthesis technique.  SPOT-synthesis is a conceptually simple, inexpensive, and highly parallel approach for the synthesis of peptides and small molecules on planar supports.  We have found that the incorporation of microwave-assisted reactions into SPOT-synthesis can expand significantly the scope of this technique.  We have developed a new support/linker system for SPOT-synthesis, established its compatibility with a range of microwave-assisted organic reactions, and extended this methodology to another cellulose support type for larger scale reactions.  This methodology allows for sizable libraries to be prepared in one day.  Our ongoing work in the design and evaluation of chalcone-derived libraries will be presented.