ORGN 642 |
Enantioselective and facially selective carbomagnesation of cyclopropenes
| Wei Luo and Joseph M. Fox. Department of Chemistry and Biochemistry, University of Delaware, 263 Brown Lab, Newark, DE 19716 |
| In this poster presentation, a new enantioselective method will be described for adding carbon nucleophiles to cyclopropenes. The combination of a prochiral center, a Grignard reagent and an electrophile create three new chiral centers in diastereo-selective reaction with up to 96%ee. The new reaction is diversity and friendly, and provides the opposite diasteroselectivity that is obtained with the Davies system for asymmetric cyclopropanation. 
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New Reactions, Methodology, Heterocycles, Aromatics
8:00 PM-10:00 PM, Wednesday, August 25, 2004 Pennsylvania Convention Center -- Hall D, Poster
Division of Organic Chemistry
The 228th ACS National Meeting, in Philadelphia, PA, August 22-26, 2004
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