Tungsten alkyne-ol cyclizations with aldehydes to form biologically interesting molecules

ORGN 789

Allen S. Kesselring, Department of Chemistry, Washington University in St. Louis, Campus Box 1134, One Brookings Drive, St. Louis, MO 63130-4899 and Scott R. Gilbertson, Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Route # 0650, Galveston, TX 77555-0650.
Tungsten alkyne-ol cyclizations with aldehydes have been used to form a set of natural product lactones that have been identified as potent inhibitors of both “normal” and “drug resistant” strains of the human malaria parasite, Plasmodium Falciparum. This reaction system is being used to synthesize natural product lactones as well as biologically interesting analogs. One of our specific aims has been to develop a polymer-bound tungsten species so that combinatorial libraries of these lactones might be available easily and in high purity. Our approach to the polymer bound tungsten species and was well as the generality of the reaction system will be discussed.

 

Combinatorial, Parallel, and Solid-Phase Chemistry
1:00 PM-5:00 PM, Thursday, August 26, 2004 Pennsylvania Convention Center -- 202B, Oral

Division of Organic Chemistry

The 228th ACS National Meeting, in Philadelphia, PA, August 22-26, 2004