Microwave-assisted asymmetric amine synthesis and C-H activation methods

ORGN 44

Jonathan A. Ellman, University of California at Berkeley
We have recently developed robust methods for carbon-carbon bond formation using two distinct conceptual approaches. The first approach utilizes enantiomerically pure tert-butanesulfinamide for the efficient asymmetric synthesis of a broad range of amine containing compounds, and the second approach utilizes C-H bond functionalization to access complex multicyclic structures from simple precursors. Herein, we will report on microwave conditions that enable previously developed procedures to be performed more efficiently, and that for new transformations enable more rapid reaction optimization.
 

Microwave-Assisted Organic Synthesis
1:00 PM-5:05 PM, Sunday, August 22, 2004 Pennsylvania Convention Center -- Ballroom A, Oral

Division of Organic Chemistry

The 228th ACS National Meeting, in Philadelphia, PA, August 22-26, 2004