ORGN 469 |
| Howard Bregman and Eric Meggers. Department of Chemistry, University of Pennsylvania, 231 S. 34th Street, Philadelphia, PA 19104 |
| Medicinal Chemistry is predominately focused on the design of purely organic molecules, whereas the incoporation of inorganic components into drugs is much less investigated. We started a research program that aims in exploring organometallic and inorganic compounds as structural scaffolds for enzyme inhibition. Such metal-ligand assemblies allow convergent synthetic approaches and give access to structural motifs that differ from purely organic molecules. Presented is a strategy for developing ruthenium complexes that target the ATP-binding site of protein kinases by copying structural features of ATP and small organic molecule inhibitors. |
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Total Synthesis, Process R&D, Combinatorial, Bioorganic, Physical Organic Chemistry
8:00 PM-10:00 PM, Tuesday, August 24, 2004 Pennsylvania Convention Center -- Hall D, Poster
Sci-Mix
Division of Organic Chemistry |